Article
Mutations equivalent to Drosophila mago nashi mutants imply reduction of Magoh protein incorporation into exon junction complex.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Jul 2022
Oshizuki Saya, Matsumoto Eri, Tanaka Satoshi, Kataoka Naoyuki
Abstract excerpt
Pre-mRNA splicing imprints mRNAs by depositing multi-protein complexes, termed exon junction complexes (EJCs). The EJC core consists of four proteins, eIF4AIII, MLN51, Y14 and Magoh. Magoh is a human homolog of Drosophila mago nashi protein, which is involved in oskar mRNA localization in Drosophila oocytes. Here we determined the effects of Magoh mutations equivalent to those of Drosophila mago nashi mutant...
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