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Unplanned pregnancies following the introduction of elexacaftor/tezacaftor/ivacaftor therapy in women with cystic fibrosis.

Archives of gynecology and obstetrics - 1 Nov 2023

Daccò Valeria, Alicandro Gianfranco, Trespidi Laura, Gramegna Andrea, Blasi Francesco Arturo

Abstract excerpt

Cystic fibrosis (CF) causes infertility and subfertility due to various factors, including altered cervical mucus, delayed puberty, and hormonal imbalances. With the introduction of the CFTR modulator therapy elexacaftor-tezacaftor-ivacaftor, we have observed an increase in unplanned pregnancies among women undergoing ETI treatment in our CF center, despite repeated recommendations for strict fertility...

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PMID: 37517074
DOI: 10.1007/s00404-023-07153-y

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