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Harnessing the Heterogeneity of Prostate Cancer for Target Discovery Using Patient-Derived Explants

28 Mar 2022

Abstract excerpt

Prostate cancer is a complex and heterogeneous disease, but a small number of cell lines have dominated basic prostate cancer research, representing a major obstacle in the field of drug and biomarker discovery. A growing lack of confidence in cell lines has seen a shift toward more sophisticated pre-clinical cancer models that incorporate patient-derived tumors as xenografts or explants, to more accurately...

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PMID: 35406480
DOI: 10.3390/cancers14071708

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