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Article

Spheroid-induced heterogeneity and plasticity of uveal melanoma cells

1 Apr 2022

Abstract excerpt

PURPOSE: The mechanism underlying cancer heterogeneity and plasticity remains elusive, in spite of the fact that multiple hypotheses have been put forward. We intended to clarify this heterogeneity in uveal melanoma (UM) by looking for evidence of cancer stem cell involvement and a potential role of ZEB1 in cancer cell plasticity. METHODS: Spheroids derived from human UM cells as well as xenograft tumors in nude...

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PMID: 35404029
DOI: 10.1007/s13402-022-00671-y

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