Article
Effect of CYP2C19 genetic variants on bleeding and major adverse cardiovascular events in a cohort of Arab patients undergoing percutaneous coronary intervention and stent implantation.
Pharmacogenetics and genomics - 1 Jul 2022
Ali Zainab Omer, Bader Loulia, Mohammed Shaaban, Arafa Salaheddin, Arabi Abdulrahman, Cavallari Larisa, Langaee Taimour, Mraiche Fatima, Rizk Nasser, Awaisu Ahmed, Shahin Mohamed H, Elewa Hazem
Abstract excerpt
INTRODUCTION: One-third of patients have clopidogrel resistance that may lead to major adverse cardiac events (MACEs). By contrast, it was found that some clopidogrel-treated patients have hyperresponsive platelets that are associated with higher bleeding risk. Several studies have shown that polymorphisms in the gene encoding the CYP2C19 contribute to the variability in response to clopidogrel. Data on genetic...
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