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Article

Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement.

Circulation - 2 Feb 2010

Sibbing Dirk, Koch Werner, Gebhard Daniela, Schuster Tibor, Braun Siegmund, Stegherr Julia, Morath Tanja, Schömig Albert, von Beckerath Nicolas, Kastrati Adnan

Abstract excerpt

BACKGROUND: The cytochrome P450 (CYP) 2C19 isoenzyme plays an important role in clopidogrel metabolization. A recently explored CYP2C19*17 allelic variant has been linked to increased transcriptional activity, resulting in extensive metabolization of CYP2C19 substrates, which may lead to an enhan...

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Source

Identifiers

PMID: 20083681
DOI: 10.1161/CIRCULATIONAHA.109.885194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20083681-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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