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Article

Enzyme kinetics and molecular modeling studies of G6PD(Mahidol) associated with acute hemolytic anemia.

Indian journal of biochemistry & biophysics - 1 Oct 2011

Lu Hui-Ru, Tang Qiong-Ling, Wang Xin, Li Hong-Jun, Li Dan-Yi, Yang Yin-Feng, Tong Shu-Fen, Zhang Chun-Hua, Zhu Yue-Chun

Abstract excerpt

G6PD(Mahidol) enzyme is the most common variant in the Achang Chinese ethnic group and clinically manifests as class II. In this study, G6PD(Mahidol) enzyme was characterized by molecular modeling to understand its kinetics. G6PD(Mahidol), G6PD(G487A) and G6PD(WT) proteins were heterologously expressed in the G6PD-deficient DF213 E. coli strain, purified and their steady-state kinetic parameters were determined....

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PMID: 22165289

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