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Canonical and Non-Canonical Functions of the Autophagy Machinery in MHC Restricted Antigen Presentation

4 Mar 2022

Abstract excerpt

Macroautophagy delivers cytoplasmic constituents for lysosomal degradation. Since major histocompatibility complex (MHC) class II molecules sample peptides after lysosomal degradation for presentation to CD4 + T cells, it was originally described that these peptides can also originate from macroautophagy substrates. In recent years it has become clear that in addition to this canonical function of the...

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PMID: 35309359
DOI: 10.3389/fimmu.2022.868888

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