Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study.

doi:10.1038/s41598-022-08058-7

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Article

Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study.

Scientific reports - 16 Mar 2022

Törn Carina, Liu Xiang, Onengut-Gumuscu Suna, Counts Kevin M, Moreno Jose Leonardo, Remedios Cassandra L, Chen Wei-Min, LeFaive Jonathon, Butterworth Martha D, Akolkar Beena, Krischer Jeffrey P, Lernmark Åke, Rewers Marian, She Jin-Xiong, Toppari Jorma, Ziegler Anette-Gabriele, Ratan Aakrosh, Smith Albert V, Hagopian William A, Rich Stephen S, Parikh Hemang M

Abstract excerpt

The Environmental Determinants of Diabetes in the Young (TEDDY) study enrolled 8676 children, 3-4 months of age, born with HLA-susceptibility genotypes for islet autoimmunity (IA) and type 1 diabetes (T1D). Whole-genome sequencing (WGS) was performed in 1119 children in a nested case-control study design. Telomere length was estimated from WGS data using five tools: Computel, Telseq, Telomerecat, qMotif and...

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PMID: 35296692
DOI: 10.1038/s41598-022-08058-7
PMCID: PMC8927592

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