Article
Characterization of a novel HLA-A*11:335 allele resulting from a rare interlocus recombination involving HLA-A*11:01:01:01/126 and HLA-H*02:07/14/18 alleles with nanopore sequencing, in a volunteer from the China Marrow Donor Program.
BMC medical genomics - 16 Mar 2022
Zhang Li-Qun, Rozemuller Erik, Wang Dan, Liu Xiang-Jun, Cai Jian-Ping
Abstract excerpt
BACKGROUND: The major histocompatibility complex (MHC) in humans includes three classical class I loci (A, B, and C), which are important biomarkers for the transplantation of organs and hematopoietic stem cells. In the MHC, polymorphism is known to be extremely high while interlocus recombination is rare. We report a rare interlocus recombination between HLA-A and HLA-H, which was analyzed using next generation...
Topics
- Alleles
- Bone Marrow
- Gene Frequency
- HLA-A Antigens
- Haplotypes
- High-Throughput Nucleotide Sequencing
- Humans
- Nanopore Sequencing
- Recombination, Genetic
- Volunteers