Prognostic Significance of DNA Methylation Profiles at MRI Enhancing Tumor Recurrence: a Report from the EORTC 26091 TAVAREC Trial.

doi:10.1158/1078-0432.CCR-21-3725

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Article

Prognostic Significance of DNA Methylation Profiles at MRI Enhancing Tumor Recurrence: a Report from the EORTC 26091 TAVAREC Trial.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2022

Draaisma Kaspar, Tesileanu C Mircea S, de Heer Iris, Klein Martin, Smits Marion, Reijneveld Jaap C, Clement Paul M, de Vos Filip Y F, Wick Antje, Mulholland Paul J, Taphoorn Martin J B, Weller Michael, Chinot Olivier L, Kros Johan M, Verschuere Tina, Coens Corneel, Golfinopoulos Vassilis, Gorlia Thierry, Idbaih Ahmed, Robe Pierre A, van den Bent Martin J, French Pim J

Abstract excerpt

PURPOSE: Despite recent advances in the molecular characterization of gliomas, it remains unclear which patients benefit most from which second-line treatments. The TAVAREC trial was a randomized, open-label phase II trial assessing the benefit of the addition of the angiogenesis inhibitor bevacizumab to treatment with temozolomide in patients with a first enhancing recurrence of World Health Organization grade 2...

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PMID: 35294545
DOI: 10.1158/1078-0432.CCR-21-3725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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