Article
GNAQ T96S mutation abrogates the ability of wild-type GNAQ to induce apoptosis by phosphorylating annexin A2 in natural killer/T cell lymphoma.
Cancer science - 1 Jul 2022
Zhao Wugan, Zhang Min, Wang Guannan, Liu Enjie, Jiang Guozhong, Zhang Yanping, Zhang Dandan, Jian Xiangyu, Zhao Haiyu, Zhang Chongli, Li Wencai
Abstract excerpt
Our previous study identified annexin A2 (ANXA2) as a Gaq-interacting partner in natural killer/T cell lymphoma (NKTCL) cells transfected with the GNAQ T96S mutation vector by immunoprecipitation and mass spectrometry; however, the detailed molecular mechanisms by which GNAQ T96S might regulate ANXA2 remain to be defined in NKTCL. Herein, we found that the GNAQ T96S mutation significantly promotes the...
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