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Recurrent GNAQ mutation encoding T96S in natural killer/T cell lymphoma

16 Sept 2019

Abstract excerpt

Abstract Natural killer/T cell lymphoma (NKTCL) is a rare and aggressive malignancy with a higher prevalence in Asia and South America. However, the molecular genetic mechanisms underlying NKTCL remain unclear. Here, we identify somatic mutations of GNAQ (encoding the T96S alteration of Gαq protein) in 8.7% (11/127) of NKTCL patients, through whole-exome/targeted deep sequencing. Using conditional knockout mice (...

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PMID: 31527657
DOI: 10.1038/s41467-019-12032-9

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