Dissecting the cross-trait effects of the FOXP2 GWAS hit on clinical and brain phenotypes in adults with ADHD.

doi:10.1007/s00406-022-01388-7

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Article

Dissecting the cross-trait effects of the FOXP2 GWAS hit on clinical and brain phenotypes in adults with ADHD.

European archives of psychiatry and clinical neuroscience - 1 Feb 2023

Meyer Gabriela Pessin, da Silva Bruna Santos, Bandeira Cibele Edom, Tavares Maria Eduarda Araujo, Cupertino Renata Basso, Oliveira Eduarda Pereira, Müller Diana, Kappel Djenifer B, Teche Stefania Pigatto, Vitola Eduardo Schneider, Rohde Luis Augusto, Rovaris Diego Luiz, Grevet Eugenio Horacio, Bau Claiton Henrique Dotto

Abstract excerpt

The Forkhead box P2 (FOXP2) encodes for a transcription factor with a broad role in embryonic development. It is especially represented among GWAS hits for neurodevelopmental disorders and related traits, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, neuroticism, and risk-taking behaviors. While several functional studies are underway to understand the consequences of FOXP2...

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PMID: 35279744
DOI: 10.1007/s00406-022-01388-7

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