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High mRNA expression of POU2F3 in small cell lung cancer cell lines predicts the effect of lurbinectedin

12 Mar 2022

Abstract excerpt

Abstract Background Small cell lung cancer (SCLC) is a progressive disease with a poor prognosis. Recently, a method to classify SCLC by the expression status of four transcription factors, ASCL1, NEUROD1, POU2F3, and YAP1, was proposed. Here, we investigated the potential relationships between expression of these four transcription factors and the effect of lurbinectedin. Methods mRNA and protein expression of...

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PMID: 35278040
DOI: 10.1111/1759-7714.14382

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