Article
PTEN alterations in sporadic and BRCA1-associated triple negative breast carcinomas.
Cancer genetics - 1 Jun 2022
Jones Natalie, Gros Audrey, Velasco Valérie, Dapremont Valérie, Brouste Véronique, Gastaldello Bernadette, Debled Marc, Tunon de Lara Christine, Bonnet Françoise, Barouk-Simonet Emmanuelle, Bubien Virginie, Venat Laurence, MacGrogan Gaëtan, Longy Michel, Sevenet Nicolas
Abstract excerpt
The similarities between sporadic basal-like breast cancer (BLBC) and BRCA1-mutated breast tumours raise the possibility that deregulation of the same pathway may underlie these tumour types. The aim of this study was to determine if PTEN aberrations are characteristic of both BRCA1 tumours and sporadic TN breast carcinomas with low BRCA1 expression, and can thus be used to identify sporadic tumours potentially...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.