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Article

Intra-specific copy number variation of MHC class II genes in the Siamese fighting fish.

Immunogenetics - 1 Jun 2022

Wong Anson Tsz Chun, Lam Derek Kong, Poon Emily Shui Kei, Chan David Tsz Chung, Sin Simon Yung Wa

Abstract excerpt

Duplicates of genes for major histocompatibility complex (MHC) molecules can be subjected to selection independently and vary markedly in their evolutionary rates, sequence polymorphism, and functional roles. Therefore, without a thorough understanding of their copy number variation (CNV) in the genome, the MHC-dependent fitness consequences within a species could be misinterpreted. Studying the intra-specific...

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PMID: 35229174
DOI: 10.1007/s00251-022-01255-8

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