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Article

CD59 deficiency is associated with chronic hemolysis and childhood relapsing immune-mediated polyneuropathy

13 Nov 2012

Abstract excerpt

CD59 deficiency is a common finding in RBCs and WBCs in patients with chronic hemolysis suffering from paroxysmal nocturnal hemoglobinuria in which the acquired mutation in the PIGA gene leads to membrane loss of glycosylphosphatidylinositol-anchored membrane proteins, including CD59. The objective of the present study was to elucidate the molecular basis of childhood familial chronic Coombs-negative hemolysis...

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PMID: 23149847
DOI: 10.1182/blood-2012-07-441857

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