Article
Implementation of CYP2D6 copy-number imputation panel and frequency of key pharmacogenetic variants in Finnish individuals with a psychotic disorder.
The pharmacogenomics journal - 1 May 2022
Häkkinen Katja, Kiiski Johanna I, Lähteenvuo Markku, Jukuri Tuomas, Suokas Kimmo, Niemi-Pynttäri Jussi, Kieseppä Tuula, Männynsalo Teemu, Wegelius Asko, Haaki Willehard, Lahdensuo Kaisla, Kajanne Risto, Kaunisto Mari A, Tuulio-Henriksson Annamari, Kampman Olli, Hietala Jarmo, Veijola Juha, Lönnqvist Jouko, Isometsä Erkki, Paunio Tiina, Suvisaari Jaana, Kalso Eija, Niemi Mikko, Tiihonen Jari, Daly Mark, Palotie Aarno, Ahola-Olli Ari V
Abstract excerpt
We demonstrate that CYP2D6 copy-number variation (CNV) can be imputed using existing imputation algorithms. Additionally, we report frequencies of key pharmacogenetic variants in individuals with a psychotic disorder from the genetically bottle-necked population of Finland. We combined GWAS chip and CYP2D6 CNV data from the Breast Cancer Pain Genetics study to construct an imputation panel (n = 902) for CYP2D6...
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