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Physical activity specifically evokes release of cell-free DNA from granulocytes thereby affecting liquid biopsy

22 Feb 2022

Abstract excerpt

Physical activity impacts immune homeostasis and leads to rapid and marked increase in cell-free DNA (cfDNA). However, the origin of cfDNA during exercise remains elusive and it is unknown if physical activity could improve or interfere with methylation based liquid biopsy. We analyzed the methylation levels of four validated CpGs representing cfDNA from granulocytes, lymphocytes, monocytes, and non-hematopoietic...

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PMID: 35193681
DOI: 10.1186/s13148-022-01245-3

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