Article
Generation of an induced pluripotent stem cell line (MUSIi014-A) from an affected member of a family with autosomal dominant diabetes carrying p.L475P mutation in ZYG11A gene associated with a cell cycle arrest in beta-cell.
Stem cell research - 1 Apr 2022
Chanprasert Chutima, Promnakhon Nutchanawan, Thongsin Nontaphat, Suwanpitak Siriwal, Plengvidhya Nattachet, Yenchitsommanus Pa-Thai, Jungtrakoon Thamtarana Prapaporn, Wattanapanitch Methichit
Abstract excerpt
A heterozygous mutation (c.T1424C: p.L475P) in ZYG11A completely segregating with hyperglycemia in a Thai family with familial diabetes of the adulthood has been reported as a cause of cell cycle arrest in 1.1B4 cell line. This mutation is a suggestive cause of failure in adaptive beta-cell expansion which, thereby, contributes to the development of diabetes in the family. Here, an induced pluripotent stem cell...
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