Article
Why is motilin active in some studies with mice, rats, and guinea pigs, but not in others? Implications for functional variability among rodents.
Pharmacology research & perspectives - 1 Apr 2022
Sanger Gareth J
Abstract excerpt
The gastrointestinal (GI) hormone motilin helps control human stomach movements during hunger and promotes hunger. Although widely present among mammals, it is generally accepted that in rodents the genes for motilin and/or its receptor have undergone pseudonymization, so exogenous motilin cannot function. However, several publications describe functions of low concentrations of motilin, usually within the GI...
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