HOXD8 hypermethylation as a fully sensitive and specific biomarker for biliary tract cancer detectable in tissue and bile samples.

doi:10.1038/s41416-022-01738-1

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HOXD8 hypermethylation as a fully sensitive and specific biomarker for biliary tract cancer detectable in tissue and bile samples.

British journal of cancer - 1 Jun 2022

Loi Eleonora, Zavattari Cesare, Tommasi Alessandro, Moi Loredana, Canale Matteo, Po Agnese, Sabato Claudia, Vega-Benedetti Ana Florencia, Ziranu Pina, Puzzoni Marco, Lai Eleonora, Faloppi Luca, Rullán María, Carrascosa Juan, Amat Irene, Urman Jesús M, Arechederra Maria, Berasain Carmen, Ferretti Elisabetta, Casadei-Gardini Andrea, Avila Matías A, Alonso Sergio, Scartozzi Mario, Zavattari Patrizia

Abstract excerpt

BACKGROUND: Biliary tract cancers (BTC) are rare but highly aggressive tumours with poor prognosis, usually detected at advanced stages. Herein, we aimed at identifying BTC-specific DNA methylation alterations. METHODS: Study design included statistical power and sample size estimation. A genome-wide methylation study of an explorative cohort (50 BTC and ten matched non-tumoral tissue samples) has been performed....

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Identifiers

PMID: 35177798
DOI: 10.1038/s41416-022-01738-1
PMCID: PMC9174245

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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