Marsdenia tenacissima extract restored gefitinib sensitivity in resistant non-small cell lung cancer cells.

doi:10.1016/j.lungcan.2011.06.001

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Article

Marsdenia tenacissima extract restored gefitinib sensitivity in resistant non-small cell lung cancer cells.

Lung cancer (Amsterdam, Netherlands) - 1 Jan 2012

Han Shu-Yan, Zhao Ming-Bo, Zhuang Gui-Bao, Li Ping-Ping

Abstract excerpt

Most non-small cell lung cancer (NSCLC) patients responding to gefitinib harbor activating mutations in the epidermal growth factor receptor (EGFR). However, the responsive cases eventually develop the resistance to gefitinib. Besides, K-ras mutations were identified as the primary resistance to gefitinib. We investigated whether Marsdenia tenacissima extract (MTE, trade name: Xiao-Ai-Ping injection) combined...

Topics

Antineoplastic Agents
Apoptosis
Carcinoma, Non-Small-Cell Lung
Cell Line, Tumor
Cell Proliferation
Drug Resistance, Neoplasm
Drug Synergism
ErbB Receptors
Gefitinib
Genes, ras
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lung Neoplasms

MAP Kinase Signaling System

Marsdenia

Mutation

Phosphorylation

Plant Extracts

Proteasome Endopeptidase Complex

Source

Open in PubMed

Identifiers

PMID: 21757251
DOI: 10.1016/j.lungcan.2011.06.001

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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