Article
Examining the Effect of Kindlin-3 Binding Site Mutation on LFA-1-ICAM-1 Bonds by Force Measuring Optical Tweezers.
Frontiers in immunology - 1 Jan 2021
McDonald Craig, Morrison Vicky L, McGloin David, Fagerholm Susanna Carola
Abstract excerpt
Integrins in effector T cells are crucial for cell adhesion and play a central role in cell-mediated immunity. Leukocyte adhesion deficiency (LAD) type III, a genetic condition that can cause death in early childhood, highlights the importance of integrin/kindlin interactions for immune system function. A TTT/AAA mutation in the cytoplasmic domain of the β2 integrin significantly reduces kindlin-3 binding to the...
Topics
- Animals
- Binding Sites
- CD18 Antigens
- CD8-Positive T-Lymphocytes
- Cell Adhesion
- Cytoskeletal Proteins
- Intercellular Adhesion Molecule-1
- Lymphocyte Activation
- Lymphocyte Function-Associated Antigen-1
- Mice
- Mutation
- Optical Tweezers