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Article

Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions.

Blood - 10 Sept 2009

Manevich-Mendelson Eugenia, Feigelson Sara W, Pasvolsky Ronit, Aker Memet, Grabovsky Valentin, Shulman Ziv, Kilic Sara Sebnem, Rosenthal-Allieri Maria Alessandra, Ben-Dor Shifra, Mory Adi, Bernard Alain, Moser Markus, Etzioni Amos, Alon Ronen

Abstract excerpt

Leukocyte adhesion deficiency (LAD)-III is associated with homozygous stop codon mutations in Kindlin-3, the hematopoietic member of the Kindlin family of integrin coactivators. In addition, a subgroup of LAD-III patients has a homozygous splice junction mutation in and reduced expression of the Rap-1 guanine nucleotide exchange factor, CalDAG-GEFI (CDGI). In this study, we compared the adhesive properties of the...

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Identifiers

PMID: 19617577
DOI: 10.1182/blood-2009-04-218636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions.PMID 19617577Read ↗

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