Bis-nor-diterpene from Cnidoscolus quercifolius (Euphorbiaceae) induces tubulin depolymerization-mediated apoptosis in BRAF-mutated melanoma cells.

doi:10.1016/j.cbi.2022.109849

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Bis-nor-diterpene from Cnidoscolus quercifolius (Euphorbiaceae) induces tubulin depolymerization-mediated apoptosis in BRAF-mutated melanoma cells.

Chemico-biological interactions - 1 Mar 2022

de Oliveira-Júnior Raimundo Gonçalves, Alves Ferraz Christiane Adrielly, de Oliveira Ana Paula, da Cruz Araújo Edigênia Cavalcante, Prunier Grégoire, Beaugeard Laureen, Groult Hugo, Picot Laurent, de Alencar Filho Edilson Beserra, El Aouad Noureddine, Rolim Larissa Araújo, Almeida Jackson Roberto Guedes da Silva

Abstract excerpt

A phytochemical investigation of cytotoxic extract and fractions of Cnidoscolus quercifolius Pohl led to isolation of five terpenoids, including three lupane-type triterpenes (1-3) and two bis-nor-diterpenes (4-5). Compounds 4 (phyllacanthone) and 5 (favelanone) are commonly found in this species and have unique chemical structure. Although their cytotoxic activity against cancer cells has been previously...

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PMID: 35150652
DOI: 10.1016/j.cbi.2022.109849

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