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Article

Stat4 rs7574865 polymorphism promotes the occurrence and progression of hepatocellular carcinoma via the Stat4/CYP2E1/FGL2 pathway.

Cell death & disease - 8 Feb 2022

Wang Caie, Gao Na, Yang Lukui, Guo Yuanyuan, Fang Yan, Wang Tong, Xu Chen, Li Gui Fang, Zhou Jun, Zhang Yunfei, Wen Qiang, Qiao Hailing

Abstract excerpt

Although there are many studies on the relationship between genetic polymorphisms and the incidence of diseases, mechanisms are rarely known. We report the mechanism by which signal transducer and activator of transcription 4 (stat4) rs7574865 promotes the occurrence and progression of hepatocellular carcinoma (HCC). We found that the GG genotype at stat4 rs7574865 was a risk genotype, and STAT4 levels in serum...

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Identifiers

PMID: 35136014
DOI: 10.1038/s41419-022-04584-4
PMCID: PMC8826371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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