Article
Maternal effect on intelligence in fragile X males and females.
American journal of medical genetics - 1 Jan 2000
Van Dyke D L, Weiss L
Abstract excerpt
If the mother is the fragile X gene carrier, her daughters (and sons) with the mutation are at high risk of mental retardation. If the father is the (clinically unaffected) carrier, his daughters are normal. This is strong evidence for a maternal effect. The decreased penetrance and variable expr...
Topics
- Dosage Compensation, Genetic
- Female
- Fragile X Syndrome
- Gene Expression Regulation
- Genetic Complementation Test
- Heterozygote
- Humans
- Intelligence
- Male
- Maternal-Fetal Exchange
- Models, Biological
- Phenotype