Modeling methylation and IQ scores in fragile X females and mosaic males.

doi:10.1002/ajmg.1320510408

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Article

Modeling methylation and IQ scores in fragile X females and mosaic males.

American journal of medical genetics - 15 Jul 1994

Kolehmainen K, Karant Y

Abstract excerpt

Both fragile X females and mosaic males carry a methylated FMR1 allele in some cells and an unmethylated allele in other cells. Due to FMR1 protein produced in cells with an unmethylated allele, these individuals are expected to display a less severe cognitive phenotype than non-mosaic affected m...

Topics

Alleles
Binomial Distribution
DNA
Dinucleoside Phosphates
Dosage Compensation, Genetic
Female
Fragile X Syndrome
Heterozygote
Humans
Intelligence
Intelligence Tests
Male
Methylation
Models, Genetic
Monte Carlo Method
Mosaicism

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