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Article

Mutational analysis of FUS gene and its structural and functional role in amyotrophic lateral sclerosis 6.

Journal of biomolecular structure & dynamics - 1 Jan 2015

Kamaraj Balu, Rajendran Vidya, Sethumadhavan Rao, Kumar Chundi Vinay, Purohit Rituraj

Abstract excerpt

Amyotrophic lateral sclerosis 6 (ALS6) is an autosomal recessive disorder caused by heterozygous mutation in the Fused in Sarcoma (FUS) gene. ALS6 is a neurodegenerative disorder, which affects the upper and lower motor neurons in the brain and spinal cord, resulting in fatal paralysis. ALS6 is caused by the genetic mutation in the proline/tyrosine-nuclear localization signals of the Fused in sarcoma Protein...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Share to RNA-Binding Protein FUS

Source

Identifiers

PMID: 24738488
DOI: 10.1080/07391102.2014.915762

Genes

FUS

Variants

Provenance

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Mutational analysis of FUS gene and its structural and functional role in amyotrophic lateral sclerosis 6.PMID 24738488Read ↗

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