Article
Increase in ADAR1p110 activates the canonical Wnt signaling pathway associated with aggressive phenotype in triple negative breast cancer cells.
Gene - 20 Apr 2022
Morales Fernanda, Pérez Paola, Tapia Julio C, Lobos-González Lorena, Herranz José Manuel, Guevara Francisca, de Santiago Pamela Rojas, Palacios Esteban, Andaur Rodrigo, Sagredo Eduardo A, Marcelain Katherine, Armisén Ricardo
Abstract excerpt
Triple-negative breast cancer (TNBC) represents a challenge in the search for new therapeutic targets. TNBCs are aggressive and generate resistance to chemotherapy. Tumors of TNBC patients with poor prognosis present a high level of adenosine deaminase acting on RNA1 (ADAR1). We explore the connection of ADAR1 with the canonical Wnt signaling pathway and the effect of modulation of its expression in TNBC....
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