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Fucosylated AGP glycopeptides as biomarkers of HNF1A-Maturity onset diabetes of the young.

Diabetes research and clinical practice - 1 Mar 2022

Tijardović Marko, Štambuk Tamara, Juszczak Agata, Keser Toma, Gasperikova Daniela, Novokmet Mislav, Tjora Erling, Pape Medvidović Edita, Stanik Juraj, Rasmus Njølstad Pål, Lauc Gordan, Owen Katharine R, Gornik Olga

Abstract excerpt

AIMS: We previously demonstrated that antennary fucosylated N-glycans on plasma proteins are regulated by HNF1A and can identify cases of Maturity-Onset Diabetes of the Young caused by HNF1A variants (HNF1A-MODY). Based on literature data, we further postulated that N-glycans with best diagnostic value mostly originate from alpha-1-acid glycoprotein (AGP). In this study we analyzed fucosylation of AGP in subjects...

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PMID: 35122907
DOI: 10.1016/j.diabres.2022.109226

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