Article
Interlaboratory evaluation of plasma N-glycan antennary fucosylation as a clinical biomarker for HNF1A-MODY using liquid chromatography methods.
Glycoconjugate journal - 1 Jun 2021
Demus Daniel, Jansen Bas C, Gardner Richard A, Urbanowicz Paulina A, Wu Haiyang, Štambuk Tamara, Juszczak Agata, Medvidović Edita Pape, Juge Nathalie, Gornik Olga, Owen Katharine R, Spencer Daniel I R
Abstract excerpt
Antennary fucosylation alterations in plasma glycoproteins have been previously proposed and tested as a biomarker for differentiation of maturity onset diabetes of the young (MODY) patients carrying a functional mutation in the HNF1A gene. Here, we developed a novel LC-based workflow to analyze blood plasma N-glycan fucosylation in 320 diabetes cases with clinical features matching those at risk of HNF1A-MODY....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.