Longitudinal changes of serum protein N-Glycan levels for earlier detection of pancreatic cancer in high-risk individuals.

doi:10.1016/j.pan.2022.03.021

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Article

Longitudinal changes of serum protein N-Glycan levels for earlier detection of pancreatic cancer in high-risk individuals.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 May 2022

Levink I J M, Klatte D C F, Hanna-Sawires R G, Vreeker G C M, Ibrahim I S, van der Burgt Y E M, Overbeek K A, Koopmann B D M, Cahen D L, Fuhler G M, Wuhrer M, Bonsing B A, Tollenaar R A E M, Vleggaar F P, Vasen H F A, van Leerdam M E, Bruno M J, Mesker W E

Abstract excerpt

BACKGROUND: Surveillance of individuals at risk of developing pancreatic ductal adenocarcinoma (PDAC) has the potential to improve survival, yet early detection based on solely imaging modalities is challenging. We aimed to identify changes in serum glycosylation levels over time to earlier detect PDAC in high-risk individuals. METHODS: Individuals with a hereditary predisposition to develop PDAC were followed in...

Topics

Blood Proteins
Carcinoma, Pancreatic Ductal
Cross-Sectional Studies
Early Detection of Cancer
Genetic Predisposition to Disease
Humans
Pancreatic Neoplasms
Polysaccharides

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PMID: 35414481
DOI: 10.1016/j.pan.2022.03.021

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