Article
Assortative mating biases marker-based heritability estimators.
Nature communications - 3 Feb 2022
Border Richard, O'Rourke Sean, de Candia Teresa, Goddard Michael E, Visscher Peter M, Yengo Loic, Jones Matt, Keller Matthew C
Abstract excerpt
Many traits are subject to assortative mating, with recent molecular genetic findings confirming longstanding theoretical predictions that assortative mating induces long range dependence across causal variants. However, all marker-based heritability estimators implicitly assume mating is random. We provide mathematical and simulation-based evidence demonstrating that both method-of-moments and likelihood-based...
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