Article
KRAS and MET in non-small-cell lung cancer: two of the new kids on the 'drivers' block.
Therapeutic advances in respiratory disease - 1 Jan 2000
Garcia-Robledo Juan Esteban, Rosell Rafael, Ruíz-Patiño Alejandro, Sotelo Carolina, Arrieta Oscar, Zatarain-Barrón Lucia, Ordoñez Camila, Jaller Elvira, Rojas Leonardo, Russo Alessandro, de Miguel-Pérez Diego, Rolfo Christian, Cardona Andrés F
Abstract excerpt
Non-small-cell lung cancer (NSCLC) is a heterogeneous disease, and therapeutic management has advanced to identify various critical oncogenic mutations that promote lung cancer tumorigenesis. Subsequent studies have developed targeted therapies against these oncogenes in the hope of personalized treatment based on the tumor's molecular genomics. This review presents a comprehensive review of the biology, new...
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