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Article

Targeted Therapies in Non-Small Cell Lung Cancer: A Contemporary Review.

American journal of clinical oncology - 1 Oct 2026

Abdelmonem Ahmed, Bikram Shah Bidhan, Shebli Mouza Al, Tabbara Imad A

Abstract excerpt

Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small cell lung carcinoma (NSCLC) comprising over 85% of cases. Advances in molecular diagnostics and precision oncology have shifted treatment toward mutation-driven strategies, resulting in significantly improved patient outcomes. This review synthesizes current evidence on the most clinically relevant genetic alterations in NSCLC...

Read the complete abstract on PubMed

Topics

Humans
Carcinoma, Non-Small-Cell Lung
Lung Neoplasms
Molecular Targeted Therapy
Protein Kinase Inhibitors
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

ErbB Receptors

Source

Identifiers

PMID: 41396253
DOI: 10.1097/COC.0000000000001275

Genes

ALK
BRAF
EGFR
KRAS
MET
RET
ROS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

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