Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization.

doi:10.1186/s12916-022-02233-3

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Article

Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization.

BMC medicine - 31 Jan 2022

Gormley Mark, Dudding Tom, Kachuri Linda, Burrows Kimberley, Chong Amanda H W, Martin Richard M, Thomas Steven J, Tyrrell Jessica, Ness Andrew R, Brennan Paul, Munafò Marcus R, Pring Miranda, Boccia Stefania, Olshan Andrew F, Diergaarde Brenda, Hung Rayjean J, Liu Geoffrey, Tajara Eloiza H, Severino Patricia, Toporcov Tatiana N, Lacko Martin, Waterboer Tim, Brenner Nicole, Smith George Davey, Vincent Emma E, Richmond Rebecca C

Abstract excerpt

BACKGROUND: Human papilloma virus infection is known to influence oropharyngeal cancer (OPC) risk, likely via sexual transmission. However, sexual behaviour has been correlated with other risk factors including smoking and alcohol, meaning independent effects are difficult to establish. We aimed to evaluate the causal effect of sexual behaviour on the risk of OPC using Mendelian randomization (MR). METHODS:...

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Identifiers

PMID: 35094705
DOI: 10.1186/s12916-022-02233-3
PMCID: PMC8802428

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