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Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2.

Cell - 17 Feb 2022

Han Pengcheng, Li Linjie, Liu Sheng, Wang Qisheng, Zhang Di, Xu Zepeng, Han Pu, Li Xiaomei, Peng Qi, Su Chao, Huang Baihan, Li Dedong, Zhang Rong, Tian Mingxiong, Fu Lutang, Gao Yuanzhu, Zhao Xin, Liu Kefang, Qi Jianxun, Gao George F, Wang Peiyi

Abstract excerpt

The coronavirus disease 2019 (COVID-19) pandemic continues worldwide with many variants arising, some of which are variants of concern (VOCs). A recent VOC, omicron (B.1.1.529), which obtains a large number of mutations in the receptor-binding domain (RBD) of the spike protein, has risen to intense scientific and public attention. Here, we studied the binding properties between the human receptor ACE2 (hACE2) and...

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Identifiers

PMID: 35093192
DOI: 10.1016/j.cell.2022.01.001
PMCID: PMC8733278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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