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Article

Triple-negative expression (ALDH1A1-/CD133-/mutant p53-) cases in lung adenocarcinoma had a good prognosis.

Scientific reports - 27 Jan 2022

Yamashita Naoki, So Tetsuya, Miyata Takeaki, Yoshimatsu Takashi, Nakano Ryuji, Oyama Tsunehiro, Matsunaga Wataru, Gotoh Akinobu

Abstract excerpt

Cancer stem cells (CSCs) are major contributors to the malignant transformation of cells because of their capacity for self-renewal. Aldehyde dehydrogenase1A1 (ALDH1A1) and CD133 are promising candidate of CSC markers in non-small cell lung cancer (NSCLC). Furthermore, TP53 is frequently mutated in lung cancer, and the loss of its function is associated with malignant characteristics. However, the relationship...

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Identifiers

PMID: 35087112
DOI: 10.1038/s41598-022-05176-0
PMCID: PMC8795115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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