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Article

Human embryonic mesenchymal lung-conditioned medium promotes differentiation to myofibroblast and loss of stemness phenotype in lung adenocarcinoma cell lines.

Journal of experimental & clinical cancer research : CR - 26 Jan 2022

Canals Jordi, Navarro Alfons, Vila Cristina, Canals Josep M, Díaz Tania, Acosta-Plasencia Melissa, Cros-Font Coralí, Han Bing, He Yangyi, Monzó Mariano

Abstract excerpt

BACKGROUND: When genes responsible for normal embryonic development are abnormally expressed in adults, it can lead to tumor development. This can suggest that the same mechanism that controls embryonic differentiation can also control tumor differentiation. We hypothesize that the malignant phenotype of lung cancer cells could acquire benign characteristics when in contact with an embryonic lung...

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Source

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Identifiers

PMID: 35081981
DOI: 10.1186/s13046-021-02206-z
PMCID: PMC8790861

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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