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SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

3 Jan 2022

Abstract excerpt

November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B.1.1.529 was announced, containing far more mutations in Spike (S) than previously reported variants. Neutralization titers of Omicron by sera from vaccinees and convalescent subjects infected with early pandemic Alpha, Beta, Gamma, or Delta are substantially reduced, or the sera failed to neutralize. Titers against Omicron are boosted by...

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PMID: 35081335
DOI: 10.1016/j.cell.2021.12.046

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