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Article

Immune Escape Associated with RBD Omicron Mutations and SARS-CoV-2 Evolution Dynamics.

Viruses - 22 Jul 2022

Kudriavtsev Aleksandr V, Vakhrusheva Anna V, Novosеletsky Valery N, Bozdaganyan Marine E, Shaitan Konstantin V, Kirpichnikov Mikhail P, Sokolova Olga S

Abstract excerpt

The evolution and the emergence of new mutations of viruses affect their transmissibility and/or pathogenicity features, depending on different evolutionary scenarios of virus adaptation to the host. A typical trade-off scenario of SARS-CoV-2 evolution has been proposed, which leads to the appearance of an Omicron strain with lowered lethality, yet enhanced transmissibility. This direction of evolution might be...

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Identifiers

PMID: 35893668
DOI: 10.3390/v14081603
PMCID: PMC9394476

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