Article
Activated phosphoinositide 3-dinase delta syndrome (APDS): An update.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Jan 2022
Lougaris Vassilios, Cancrini Caterina, Rivalta Beatrice, Castagnoli Riccardo, Giardino Giuliana, Volpi Stefano, Leonardi Lucia, La Torre Francesco, Federici Silvia, Corrente Stefania, Cinicola Bianca Laura, Soresina Annarosa, Marseglia Gian Luigi, Cardinale Fabio
Abstract excerpt
Activated phosphoinositide 3-kinase delta syndrome (APDS) is a recently described form of inborn error of immunity (IEI) caused by heterozygous mutations in PIK3CD or PIK3R1 genes, respectively, encoding leukocyte-restricted catalytic p110δ subunit and the ubiquitously expressed regulatory p85 α subunit of the phosphoinositide 3-kinase δ (PI3Kδ). The first described patients with respiratory infections,...
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