Article
Longitudinal analysis of SARS-CoV-2 spike and RNA-dependent RNA polymerase protein sequences reveals the emergence and geographic distribution of diverse mutations.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jan 2022
Showers William M, Leach Sonia M, Kechris Katerina, Strong Michael
Abstract excerpt
Amid the ongoing COVID-19 pandemic, it has become increasingly important to monitor the mutations that arise in the SARS-CoV-2 virus, to prepare public health strategies and guide the further development of vaccines and therapeutics. The spike (S) protein and the proteins comprising the RNA-Dependent RNA Polymerase (RdRP) are key vaccine and drug targets, respectively, making mutation surveillance of these...
Topics
- Adenosine Monophosphate
- Africa
- Alanine
- Amino Acid Substitution
- Angiotensin-Converting Enzyme 2
- Antiviral Agents
- Asia
- Binding Sites
- COVID-19
- Coronavirus RNA-Dependent RNA Polymerase