Article
Non-additive QTL mapping of lactation traits in 124,000 cattle reveals novel recessive loci.
Genetics, selection, evolution : GSE - 24 Jan 2022
Reynolds Edwardo G M, Lopdell Thomas, Wang Yu, Tiplady Kathryn M, Harland Chad S, Johnson Thomas J J, Neeley Catherine, Carnie Katie, Sherlock Richard G, Couldrey Christine, Davis Stephen R, Harris Bevin L, Spelman Richard J, Garrick Dorian J, Littlejohn Mathew D
Abstract excerpt
BACKGROUND: Deleterious recessive conditions have been primarily studied in the context of Mendelian diseases. Recently, several deleterious recessive mutations with large effects were discovered via non-additive genome-wide association studies (GWAS) of quantitative growth and developmental traits in cattle, which showed that quantitative traits can be used as proxies of genetic disorders when such traits are...
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