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Article

Estrogen receptor beta increases clear cell renal cell carcinoma stem cell phenotype via altering the circPHACTR4/miR-34b-5p/c-Myc signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2022

Wang Yaxuan, Yang Zhan, Gu Junfei, Zhang Yanping, Wang Xin, Teng Zhihai, Wang Dandan, Gao Lei, Li Wei, Yeh Shuyuan, Han Zhenwei

Abstract excerpt

Early clinical studies indicated that estrogen receptor beta (ERβ) might play key roles to impact the progression of clear cell renal cell carcinoma (ccRCC). The detailed molecular mechanisms, however, remain unclear. Here, we found ERβ could increase the cancer stem cell (CSC) population via altering the circPHACTR4/miR-34b-5p/c-Myc signaling. Mechanism dissection revealed that ERβ could suppress circular RNA...

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PMID: 35061326
DOI: 10.1096/fj.202101645R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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