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Article

Abnormal exocrine-endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8.

Nature metabolism - 1 Jan 2022

Kahraman Sevim, Dirice Ercument, Basile Giorgio, Diegisser Danielle, Alam Jahedul, Johansson Bente B, Gupta Manoj K, Hu Jiang, Huang Ling, Soh Chew-Li, Huangfu Danwei, Muthuswamy Senthil K, Raeder Helge, Molven Anders, Kulkarni Rohit N

Abstract excerpt

MODY8 (maturity-onset diabetes of the young, type 8) is a dominantly inherited monogenic form of diabetes associated with mutations in the carboxyl ester lipase (CEL) gene expressed by pancreatic acinar cells. MODY8 patients develop childhood-onset exocrine pancreas dysfunction followed by diabetes during adulthood. However, it is unclear how CEL mutations cause diabetes. In the present study, we report the...

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PMID: 35058633
DOI: 10.1038/s42255-021-00516-2

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Abnormal exocrine-endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8.PMID 35058633Read ↗

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Generation of β Cells from iPSC of a MODY8 Patient with a Novel Mutation in the Carboxyl Ester Lipase (CEL) Gene.Semantic proximity Read ↗

Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY): a protein misfolding disease.Semantic proximity Read ↗

Pathogenic Carboxyl Ester Lipase (CEL) Variants Interact with the Normal CEL Protein in Pancreatic Cells.Semantic proximity Read ↗

Two New Mutations in the CEL Gene Causing Diabetes and Hereditary Pancreatitis: How to Correctly Identify MODY8 Cases.Semantic proximity Read ↗

Identification of a Novel Mutation in Carboxyl Ester Lipase Gene in a Patient with MODY-like Diabetes.Semantic proximity Read ↗

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A Carboxyl Ester Lipase (CEL) Mutant Causes Chronic Pancreatitis by Forming Intracellular Aggregates That Activate Apoptosis.Semantic proximity Read ↗

Clinical and genetic characteristics of CEL-MODY (MODY8): a literature review and screening in Chinese individuals diagnosed with early-onset type 2 diabetes.Semantic proximity Read ↗

Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (maturity-onset diabetes of the young).Semantic proximity Read ↗

A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis.Semantic proximity Read ↗

The CEL-HYB1 Hybrid Allele Promotes Digestive Enzyme Misfolding and Pancreatitis in Mice.Semantic proximity Read ↗

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