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Article

Clinical Spectrum of SCN5A Channelopathy in Children with Primary Electrical Disease and Structurally Normal Hearts.

Genes - 22 Dec 2021

Villarreal-Molina Teresa, García-Ordóñez Gabriela Paola, Reyes-Quintero Álvaro E, Domínguez-Pérez Mayra, Jacobo-Albavera Leonor, Nava Santiago, Carnevale Alessandra, Medeiros-Domingo Argelia, Iturralde Pedro

Abstract excerpt

Sodium voltage-gated channel α subunit 5 (SCN5A)-mutations may cause an array of arrhythmogenic syndromes most frequently as an autosomal dominant trait, with incomplete penetrance, variable expressivity and male predominance. In the present study, we retrospectively describe a group of Mexican patients with SCN5A-disease causing variants in whom the onset of symptoms occurred in the pediatric age range. The...

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Source

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Identifiers

PMID: 35052356
DOI: 10.3390/genes13010016
PMCID: PMC8774384

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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